Piezoelectric Activation Device: An Innovative Approach for Embryo Activation After ICSI
Piezoelectric activation technology is a method developed to support oocyte activation, particularly following intracytoplasmic sperm injection (ICSI), in the in vitro fertilization (IVF) process. This technology enables the controlled permeability of the cellular membrane by applying an electrical stimulus to the oocyte content through electroporation. Electroporation triggers calcium oscillations, initiating the fertilization process and positively influencing embryonic development. Scientific studies have shown that this method can contribute to the improvement of embryo development post-fertilization (Ebner et al., 2012; Tosti & Ménézo, 2016).
Advantages of Piezoelectric Activation:
Increased Oocyte Activation: Piezoelectric activation applied after ICSI can support early embryo development, potentially improving success rates. Clinical research has demonstrated that piezoelectric-based activation can significantly enhance fertilization rates in patients with oocyte activation deficiencies.
A Process Closer to Physiological Activation: Compared to traditional chemical activation methods, piezoelectric technology provides a more natural and controlled cellular activation. Studies show that piezoelectric methods cause minimal damage to the oocyte membrane and regulate calcium ion flow, supporting embryo development (Zhang et al., 2020).
Precise and Reproducible Application: Piezo-assisted electroporation allows for oocyte activation without causing harm, applying specific electrical parameters to ensure a precise and reproducible process.
Supporting Embryo Development Potential: Piezoelectric activation can increase the chances of the embryo reaching the blastocyst stage after fertilization. This is associated with higher implantation rates in embryo culture processes (Kimura & Yanagimachi, 1995).
Applications
Piezoelectric activation can be particularly useful in cases of oocyte activation failure and couples who have experienced previous ICSI fertilization failures. This technology helps optimize the oocyte activation process post-fertilization, enhancing the embryo’s developmental potential.
The Piezoelectric Activation Device offers an effective solution to improve embryo development, supported by scientific evidence and trusted as a reliable method in IVF laboratories.